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Tytuł: Resistance to clopidogrel treatment in patients with coronary artery disease

Autor:

Dziewierz, Artur

Data:

2008

Typ:

Praca doktorska

Abstrakt:

Background: Clopidogrel reduces ischemic events rate in patients (pts) with coronary artery disease (CAD). In some pts inhibitory effect of clopidogrel is weakly expressed despite use of recommended loading dose (LD). Aim: To assess frequency and possibility of early identification of clopidogrel resistance. Methods: In 60 pts with CAD platelet aggregation inhibition (DPAI) was assessed at baseline and 3, 6, 12 as well as 24 h and 30 days after administration of clopidogrel LD (300 mg). Response to clopidogrel was calculated as absolute difference between the baseline DPAI and DPAI obtained at the investigated time-points (ΔDPAI). Results: After 24 h from clopidogrel LD 14 (23.33%) pts were identified as non-responders (ΔDPAI ≤10%). Demographic and clinical variables were similar in responders and non-responders. ΔDPAI assessed at 6 h correlated well with ΔDPAI at 24 h (r=0.75; p<0.001). No differences in the rate of ischemic or bleeding complications between groups were noted. Conclusions: Resistance to clopidogrel is frequent among CAD patients. There is no significant correlation between resistance to clopidogrel phenomenon and demographic characteristics, as well as concomitant pharmacological treatment. Early identification of pts resistant to clopidogrel is possible and may be used in everyday clinical practice.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

choroby układu krążenia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Dubiel, Jacek

Data wydania:

2007

Identyfikator:

oai:dl.cm-uj.krakow.pl:1005

Sygnatura:

ZB-107617

Język:

pol

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

clopidogrel resistance percutaneous coronary interventions antiplatelet agents coronary artery disease

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

21 lis 2012

Liczba wyświetleń treści obiektu:

626

Liczba wyświetleń treści obiektu w formacie PDF

160

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/1005

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Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-107617 26 cze 2023

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Adres

Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

Telefon

12 658 72 56
517 385 669

E-Mail

Oddział Gromadzenia i Opracowania Zbiorów
cyfrowabm@cm-uj.krakow.pl

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