Advanced search ?

Object

Download

Title: Resistance to clopidogrel treatment in patients with coronary artery disease

Author:

Dziewierz, Artur

Date:

2008

Type:

Praca doktorska

Abstract:

Background: Clopidogrel reduces ischemic events rate in patients (pts) with coronary artery disease (CAD). In some pts inhibitory effect of clopidogrel is weakly expressed despite use of recommended loading dose (LD). Aim: To assess frequency and possibility of early identification of clopidogrel resistance. Methods: In 60 pts with CAD platelet aggregation inhibition (DPAI) was assessed at baseline and 3, 6, 12 as well as 24 h and 30 days after administration of clopidogrel LD (300 mg). Response to clopidogrel was calculated as absolute difference between the baseline DPAI and DPAI obtained at the investigated time-points (ΔDPAI). Results: After 24 h from clopidogrel LD 14 (23.33%) pts were identified as non-responders (ΔDPAI ≤10%). Demographic and clinical variables were similar in responders and non-responders. ΔDPAI assessed at 6 h correlated well with ΔDPAI at 24 h (r=0.75; p<0.001). No differences in the rate of ischemic or bleeding complications between groups were noted. Conclusions: Resistance to clopidogrel is frequent among CAD patients. There is no significant correlation between resistance to clopidogrel phenomenon and demographic characteristics, as well as concomitant pharmacological treatment. Early identification of pts resistant to clopidogrel is possible and may be used in everyday clinical practice.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Dubiel, Jacek

Date issued:

2007

Identifier:

oai:dl.cm-uj.krakow.pl:1005

Call number:

ZB-107617

Language:

pol

Access rights:

nieograniczony

Subject and keywords:

clopidogrel resistance percutaneous coronary interventions antiplatelet agents coronary artery disease

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Nov 21, 2012

Number of object content hits:

690

Number of object content views in PDF format

237

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1005

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-107617 Jun 26, 2023

Objects

Similar

Resistance to clopidogrel treatment in patients with coronary artery disease

Dziewierz, Artur

2008
Praca doktorska

Effect of early abciximab in ST-elevation myocardial inrafction patients treated with mechanical reperfusion on outcome in high risk subgroup

Siudak, Zbigniew

2009
Praca doktorska

Knowledge about recanalization of chronic total coronary arteryocclusions among polish physicians, cardiologists and interventional cardiologists

Bryniarski, Krzysztof

2016
Praca doktorska

Treatment strategy assessment in patients with acute myocardialinfarction in municipal hospital before and after the introduction of24/7 primary PCI service

Januś, Bogdan

2012
Praca doktorska

Prediction of infarct size and post-infarct left ventricular remodeling in patients with ST-elevation myocardial infarction treated with percutaneous coronary angioplasty

Lech, Piotr

2015
Praca doktorska

Coronary microcirculatory dysfunction in patients with chronic coronary syndrome

Niewiara, Łukasz

2022
Praca doktorska

Oral health in patients with myocardial infarction treated by primary angioplasty

Stryjewska, Katarzyna

2020
Praca doktorska

Prehospital abciximab administration in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention

Rakowski, Tomasz

2007
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information