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Title: Resistance to clopidogrel treatment in patients with coronary artery disease

Author:

Dziewierz, Artur

Date:

2008

Type:

Praca doktorska

Abstract:

Background: Clopidogrel reduces ischemic events rate in patients (pts) with coronary artery disease (CAD). In some pts inhibitory effect of clopidogrel is weakly expressed despite use of recommended loading dose (LD). Aim: To assess frequency and possibility of early identification of clopidogrel resistance. Methods: In 60 pts with CAD platelet aggregation inhibition (DPAI) was assessed at baseline and 3, 6, 12 as well as 24 h and 30 days after administration of clopidogrel LD (300 mg). Response to clopidogrel was calculated as absolute difference between the baseline DPAI and DPAI obtained at the investigated time-points (ΔDPAI). Results: After 24 h from clopidogrel LD 14 (23.33%) pts were identified as non-responders (ΔDPAI ≤10%). Demographic and clinical variables were similar in responders and non-responders. ΔDPAI assessed at 6 h correlated well with ΔDPAI at 24 h (r=0.75; p<0.001). No differences in the rate of ischemic or bleeding complications between groups were noted. Conclusions: Resistance to clopidogrel is frequent among CAD patients. There is no significant correlation between resistance to clopidogrel phenomenon and demographic characteristics, as well as concomitant pharmacological treatment. Early identification of pts resistant to clopidogrel is possible and may be used in everyday clinical practice.

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Jacek S. Dubiel

Date issued:

2007

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:1005

Call number:

ZB-107617

ControlNumberVIRTUA:

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Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego - Collegium Medicum

Subject and keywords:

clopidogrel coronary artery disease resistance antiplatelet agents percutaneous coronary interventions

Object collections:

Last modified:

Jun 27, 2019

In our library since:

Nov 21, 2012

Number of object content hits:

449

Number of object content views in PDF format

446

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/1005

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Edition name Date
ZB-107617 Jun 27, 2019

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