TY - GEN A1 - Więckowski, Krzysztof N2 - The aim of this study was rational design, synthesis and determination of physicochemical and pharmacological properties of series of new yhydroxybutyric acid (GHB) and y-butyrolactone (GBL) derivatives. The main part of the study was chemical synthesis of about hundred compounds utilizing different classical and modern methods, e.g. microwave-assisted organie synthesis (MAOS). For selected compounds various physicochemical descriptors were assigned with the use of computational and experimental methods as well. The pharmacological tests carried out as a part of the Anticonvulsant Screening Project (ASP, NIH, Rockville, USA) and in collaboration with Dept. of Pharmacodynamics of Jagiellonian University, revealed anticonvulsant and strong analgesic activity of some derivatives. Results of chemical and pharmacological investigations and SAR analysis led to select the most anticonvulsant and analgesic active compounds for further extending testing. CY - Kraków L2 - http://dl.cm-uj.krakow.pl:8080/Content/854 PY - 2008 KW - analgesic activity KW - chemical synthesis KW - [gamma]-methoxybutyramides KW - anticonvulsant activity KW - [gamma]-hydroxybutyramides T1 - Synthesis and pharmacological properties of novel derivatives of [gamma]-butyrolacotone and amides of [gamma]-hydroxybutyric acid UR - http://dl.cm-uj.krakow.pl:8080/dlibra/publication/edition/854 ER -