TY - GEN A1 - Płatek, Joanna N2 - The aim of this study was to assess the relationship between plasma trace elements concentration (iron, copper and zinc), their 24-hour urinary excretion, plasma metalloprotein concentration (ferritin, ceruloplasmin) and blood pressure (BP) values, the prevalence of hypertension and indicators of cardiac and vascular organ damage typical for hypertension. The study group included 303 individuals, recruited from the general population (138 parents; 165 offspring, 136M/167F). In addition anthropometric measures, conventional BP measurements and 24-hour ambulatory BP monitoring, echocardiography, carotid ultrasonography and arterial applanation tonometry were provided. Iron, copper and zinc plasma concentration and 24-hour urinary excretion was assessed by ICP-MS (Inductively Coupled Plasma Mass Spectrometry). Selected metalloproteins of these metals (ferritin, ceruroplasmin) were determined by the ELISA test. Database management and statistical analysis were performed with SAS software (SAS Institute, Cary, NC), version 9.3. In this study the association of iron and copper homeostasis with blood pressure (BP) values and the association of three metals under study with vascular complications were shown. The results in the future may contribute to the further research into the pathogenesis of hypertension. CY - Kraków L2 - http://dl.cm-uj.krakow.pl:8080/Content/4061 PY - 2015 KW - iron KW - zinc KW - organ damage KW - copper KW - hypertension T1 - Role of metalloproteins containing copper, zinc or iron in pathogenesis of organ changes in hypertension UR - http://dl.cm-uj.krakow.pl:8080/dlibra/publication/edition/4061 ER -