TY - GEN A1 - Partyka, Anna N2 - In present study the anticonvulsant-, anxiolytic- and antidepressant-like activity of two groups of γ-aminobutyric acid (GABA) derivatives: 6 amide GABA analogues and 3 phosphinic acid analogues were examined. Results of GABA amide derivatives demonstrate that some of these compounds had anticonvulsant- and/or antidepressant-like activity. None of six investigated GABA amide analogues exihibited the affinity to GABA-ergic receptors, thus their pharmacological effects are not mediated by direct interaction with GABA-ergic neurotransmission. The preliminary screening of three phosphinic acid analogues showed anticonvulsant-like activity of the GABAB receptors agonist (CGP 44532), anxiolytic-like effects of the GABAB receptors antagonist (CGP 36742) and antidepressant-like properties of the GABAB receptors antagonists (CGP 36742, CGP 51176). CGP 44532 antagonizes the antidepressant-like activity of CGP 51176 in the forced swim test in mice, which indicates that this effect is mediated by GABAB receptors. Moreover, chronic treatment with CGP 51176 induced GABAB receptor up-regulation in mouse hippocampus. Obtained data indicate that GABAB receptor antagonism may serve as a basis for the creation of novel antidepressants and support the hypothesis of involvement of GABA-ergic system in the mechanism of antidepressant therapy. CY - Kraków L2 - http://dl.cm-uj.krakow.pl:8080/Content/1128 PY - 2006 KW - GABAB receptors KW - anxiety KW - convulsions KW - depression KW - GABA T1 - The examination of neuropsychotropic properties of some new [gamma]-aminobutyric acid derivatives (GABA) UR - http://dl.cm-uj.krakow.pl:8080/dlibra/publication/edition/1128 ER -