@misc{Kaleta_Katarzyna_Epidemiology,_2021,
 author={Kaleta, Katarzyna},
 address={Kraków},
 howpublished={online},
 year={2021},
 school={Rada Dyscypliny Nauki medyczne},
 language={pol; eng},
 abstract={Aim: The first aim of the study was to perform the epidemiological characteristics of patients affected by acne vulgaris (AV) and hidradenitis suppurativa (HS). Specifically, an attempt was made to determine the conditions accompanying AV in the Cracow’s population of patients, to distinguish specific features of the adult female acne subpopulation (AFA) and to assess the co-existence of other autoinflammatory conditions associated with AV/HS via a systematic review of the literature. The second aim was to evaluate the role of obesity, nicotinism, and inflammation in the pathogenesis of HS using an immunohistochemical analysis of expression of the selected protein markers in the skin of obese smokers (OS) compared to non-obese and non-smokers (NN). Material and methods: The study was conducted at the Department of Dermatology, Jagiellonian University Medical College in Cracow, where a retrospective analysis of medical records of 354 patients with acne vulgaris was performed. The second part of the research was an immunohistochemical study on skin sections of 22 patients (10 NN, 12 OS) surgically treated for HS in Dessau, Germany at the Brandenburg Theodor Fontane Medical University, Department of Dermatology, Venereology, Allergology and Immunology. Formalin-fixed, paraffinembedded skin sections were sliced with a microtome into 3.5-micrometer cuts and then stained with antib},
 abstract={odies against proteins associated with obesity (PPAR-γ, irisin, IGFR- 1R), smoking/proliferation (AhR, EGFR), and inflammatory markers (IL-17 and its’ receptor, S100A8/MRP8); antibodies delivered by Abcam, Berlin, Germany. Epidermis and dermis specimens were photographed (x100 magnification; EVOS AMG microscope, Bothell, Washington). The computer program FIJI (Fiji Is Just ImageJ; NIH, Bethesda, USA) and a semi-automatic procedure (Andy's algorithm) were used to analyze the microscopic images. Finally, a systematic review of articles collected in the electronic databases MEDLINE, EMBASE and CENTRAL in the period of 1980-2020 was performed by two independent investigators to identify the cases in which acne vulgaris/acne inversa was accompanied by at least two other autoinflammatory diseases. Results: In the first retrospective study of patients with acne vulgaris, 61% of individuals were female and 27.6 % of all patients classified as AFA. The median age in the study was 24 years, for AFA it was 32.5 years. Patients with AFA were less likely to have skin lesions on the back, and the face was the most commonly affected area. Papulopustular acne predominated in the whole population studied. In 38.7% of all subjects at least one chronic systemic disease was present, with endocrine disorders being the most common (15.25%), and thyroid dysfunction present in 6.21%. Endocrine disord},
 abstract={ers were significantly more frequent in women with AFA than in other patients, while cutaneous features of hyperandrogenism were less frequent in AFA. Furthermore, in the immunohistochemical examination of the skin probes of HS patients, peptides associated with obesity showed differential expression between groups, whereas peptides associated with smoking were not significantly different between OS and NN. EGFR manifested stronger in the NN than OS group. IL-17R showed greater immunoreactivity in the OS group, whereas S100A8 staining showed a substantial, increased expression in all subjects. Finally, in our third study a systematic literature review identified 64 articles on syndromic HS. The articles included those regarding already well-defined syndromes as well as new, previously undescribed constellations of symptoms, for instance with ocular involvement. Cutaneous symptoms, including HS, usually preceded symptoms from other organs, and they proved resistant to conventional therapy in a significant proportion of patients. Conclusions: The results of the study indicate that metabolic disorders (obesity) play a pivotal role in the pathogenesis of acne inversa, while the impact of smoking is less prominent. A special subgroup of women with acne present >25 years of age was identified, which is a growing health problem nowadays: in this population acne may constitute an isol},
 abstract={ated manifestation of hyperandrogenism, therefore a screening for concomitant hormonal disorders is warranted. Severe forms of AV or HS can be a harbinger of systemic autoinflammatory syndromes such as SAPHO, PASH, PAPASH, PsAPASH, or PASS, hence early diagnosis and treatment are necessary to prevent the "autoinflammatory march".},
 title={Epidemiology, risk factors, and novel immunohistochemical approach aiming to undercover the pathogenesis of selected diseases of the pilosebaceous units (acne inversa and acne vulgaris)},
 type={Praca doktorska},
 keywords={acne vulgaris, hidradenitis suppurativa, autoinflammatory disease, risk factors, adult female acne, obesity, smoking, interleukin-17},
}