@misc{Domagała_Angelika_The_2022,
 author={Domagała, Angelika},
 address={Kraków},
 howpublished={online},
 year={2022},
 school={Rada Dyscypliny Nauki medyczne},
 language={pol; eng},
 abstract={Opsonin-independent macrophage scavenger-mediated macrophagemediated phagocytosis is an early mechanism of host antimicrobial defense. The ability to bind bacteria is common to all types of SR. Most studies have used fluorescently labeled surface altered bacteria. In addition, the increased susceptibility to Staphylococcus aureus (Sa) infections in SR-A / CD204- or CD36-deficient mice was attributed to macrophage-mediated impairment of phagocytosis, which, however, contradicts the low efficacy of unopsonized Sa phagocytosis in macrophages. In our study, we observed that, unlike the phagocytosis of killed and fluorescently labeled bacteria used in previous experiments, phagocytosis of non-opsonized live bacteria is less efficient and not impaired in CD36 or SR-A / CD204 deficient macrophages. Our results also show that the SR-A / CD204 and CD36 receptors influence Sa-stimulated cytokine production in murine macrophages differently depending on the dose of the bacteria. Acting as coreceptors and regulators of endocytosis, CD36 and SR-A enable intracellular activation of the Toll-like receptor 2 (TLR2) by lower doses of bacteria. However, at higher doses of bacteria, the participation of both receptors in TLR2 activation becomes redundant and their inhibitory effect on cytokine production begins to prevail.},
 title={The role of the CD36 and SR-A / CD204 scavenger receptors in the fight against bacterial infections},
 type={Praca doktorska},
 keywords={scavenger receptors, Toll-like receptor 2, Staphylococcus aureus, cytokine, phagocytosis},
}