@misc{Głuch-Lutwin_Monika_Characteristics_2022,
 author={Głuch-Lutwin, Monika},
 address={Kraków},
 howpublished={online},
 year={2022},
 school={Wydział Farmaceutyczny},
 language={pol},
 abstract={The first part of the dissertation describes in vitro studies of the functional profile for new selective 5-HT1A receptor ligands. For the first time, they included the parallel characterization of several dozen 5-HT1A receptor ligands in several signaling pathways (cAMP inhibition, ERK1/2 phosphorylation, Ca2+ mobilization, β-arrestin recruitment), which resulted in a pioneering discovery of numerous and diverse functional profiles. Ligands with higher than before functional selectivity for ERK1/2 phosphorylation have been described, as well as for the first time ligands with a clear preference for β-arrestin recruitment. In vivo studies investigated the potential antidepressant properties of four selected 5-HT1A receptor biased agonists, both in the basic forced swimming test in mice and, for the first time, for such ligands, in murine models of corticosterone-induced depression and unpredictable chronic mild stress. The tested compounds showed significant activity after a single administration, which distinguishes them from the currently available antidepressants, and the behavioral effects were correlated with favorable changes in the level of pERK1/2 in the frontal cortex and hippocampus. The impact of the tested compounds on the consolidation process of memory traces in the novel object recognition test was also assessed.},
 title={Characteristics of functional selectivity new 5-HT1A serotonin receptor agonists},
 type={Praca doktorska},
 keywords={functional selectivity, 5-HT1A serotonin receptor, 5-HT1A agonists, depression},
}