@misc{Kotlarz_Agnieszka_Serological_2021,
 author={Kotlarz, Agnieszka},
 address={Kraków},
 howpublished={online},
 year={2021},
 school={Wydział Nauk o Zdrowiu},
 language={pol},
 abstract={Syphilis is an infection caused by Treponema pallidum. Pregnancy has little effect on the clinical picture of syphilis, but syphilis infection can complicate pregnancy. Methods: 24 patients with early syphilis, 14 of whom were pregnant, were included in the study. Blood was drawn for testing according to the study protocol. A single dose of penicillin was administered. Follow-up was conducted until a normal serological response to treatment was achieved. Results: The analyzed groups did not differ statistically significantly in the results of basic blood parameters. 6 months after the end of treatment, 42.9% of pregnant patients were characterized by an abnormal serologic response to treatment, at which time a normal serologic response was noted in all non-pregnant patients. Pregnant women with syphilis were characterized by statistically significantly higher concentrations of cytokines typical of the regulatory response before and 6 months after the end. After treatment, concentrations of cytokines typical of regulatory response decreased significantly in both groups; the older the pregnancy at the time of syphilis diagnosis, the statistically significantly longer time required to achieve a normal serological response to treatment. Conclusions: Pregnant patients treated for syphilis during pregnancy are characterized by a slower serological response to tr},
 abstract={eatment. The predominance of regulatory mechanisms over inflammatory mechanisms in the response to infection and that associated with pregnancy itself may be an explanation. Treatment of syphilis in pregnancy with penicillin is safe for mother and child.},
 title={Serological response to treatment of early syphilis in pregnant women},
 type={Praca doktorska},
 keywords={early syphilis, syphilis in pregnancy, serofast syphilis, immunology of pregnancy},
}