@misc{Skowron_Kamil_Analysis_2022,
 author={Skowron, Kamil},
 address={Kraków},
 howpublished={online},
 year={2022},
 school={Wydział Lekarski},
 language={pol; eng},
 abstract={The modern model explaining the onset and development of anorexia nervosa (AN) recognizes a distinct dysfunction in metabolic pathways that induce or at least potentiate multisystemic clinical symptoms. The main objective of this study was to explore the neurobiological basis of AN by assessing the effect of exogenous kisspeptin on the development and course of abnormalities observed in an animal model of activity-based anorexia (ABA). Peripheral and central neurohormonal disturbances of the ABA model were analyzed. Using magnetic resonance spectroscopy, a neurochemical profile of the hypothalamus and brainstem of the animals studied was developed. The obtained spectra of brain metabolites showed an imbalance reflecting the effects of ABA on local energy balance and adaptive antioxidant mechanisms. Kisspeptin administered subcutaneously alleviated ABA modeling by altering the pattern of weight loss. In addition, partial normalization of GABA and creatine levels (hypothalamus) as well as restoration of basal glutamate levels (brainstem) was achieved in brain centers responsible for the regulation of appetite and satiety. The results obtained indicate that kisspeptin potentially through modulation of hypothalamic GABA-ergic signaling increases food intake and thus positively affects brain metabolism.},
 title={Analysis of the effects of a novel neuropeptide – kisspeptin –on peripheral and central mechanisms of metabolic dysfunction in an animal model of activity-based anorexia},
 type={Praca doktorska},
 keywords={anorexia nervosa, activity-based anorexia, kisspeptin, neurochemical profile, hypothalamus},
}