@misc{Wąsik_Magdalena_Natalia_Studies_2021,
 author={Wąsik, Magdalena Natalia},
 address={Kraków},
 howpublished={online},
 year={2021},
 school={Rada Dyscypliny Nauki medyczne},
 language={pol},
 abstract={Cow's milk is one of the most common causes of food allergies among children, and caseins constitute 80% of its proteins. There is a group of patients in whom allergic reaction to cow's milk is delayed, possibly cell-mediated. Recent discoveries have shown that excessive cellular response can be inhibited using specific suppressive exosomes with miRNA-150. The aim of the research was to describe the mechanism of delayed-type hypersensitivity (DTH) reaction to casein in mice and to evaluate the potential therapeutic application of casein-specific suppressive exosomes. In the present study, it was shown that DTH reaction to casein in mice is mediated by CD4 + Th1 lymphocytes and macrophages. The suppressive properties of casein-specific exosomes were confirmed in adoptive transfer in vitro and in a mouse model of DTH to casein in vivo. The strongest suppression effect was obtained with the oral route of exosomes administration. doktorat},
 title={Studies of a mouse model of delayed-type hypersensitivity to casein with a test of antigen-specific immunosuppression},
 type={Praca doktorska},
 keywords={casein, delayed-type hypersensitivity, cow’s milk, exosomes, miRNA-150},
}