@misc{Pirowska_Magdalena_Evaluation_2018,
 author={Pirowska, Magdalena},
 address={Kraków},
 howpublished={online},
 year={2018},
 school={Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.},
 abstract={INTRODUCTION: Psoriasis is a common chronic skin disease. In recent years,research has shown the association of dermatosis with numerous accompanyingdiseases, most often with cardiovascular diseases and metabolic syndrome,determining psoriasis as a predisposing factor.OBJECTIVE: The aim of this dissertation was to evaluate the epidemiology ofpatients with psoriasis and psoriatic arthritis and to study the levels of TNF-α, IL-12,IL-23 and IL-17 in patients’ blood in correlation with individual components of themetabolic syndrome.MATERIAL AND METHODS: A retrospective study evaluated data from 3,331hospitalizations and 1,537 outpatient cards of patients with psoriasis. For the studyof cytokines 60 patients with severe psoriasis were included. Control groups were:15 subjects diagnosed with metabolic syndrome and 15 healthy voluntary subjects.The concentrations of IL-12, IL-17, IL-23 and TNF-α in serum were determined.RESULTS: The level of the studied cytokines: IL-23 and TNF-α was higher inpatients diagnosed with psoriasis in comparison to the control group. Higher levelsof IL-17 were observed in patients with metabolic syndrome associated withpsoriasis. The level of cytokines was also assessed in relation to the presence ofspecific co-morbidities that are components of the metabolic syndrome. The level ofIL-17 was higher in the group of patients diagnosed with diabetes mellitus anddislipidemia. In the study, a higher level of IL-17 and IL-23 was also shown, inpatients with psoriatic arthritis in comparison to patients with normal psoriasis.CONCLUSIONS: It seems very important to study immunologic mechanismsresponsible for the presence of psoriasis to personalize the therapy and optimize theeffect of action on the basic disease and on concomitant disorders.*},
 title={Evaluation of selected proinflammatory cytokines in psoriatic and psoriatic arthritis patients with coexisting metabolic syndrome},
 type={Praca doktorska},
 keywords={psoriasis, psoriatic arthritis, metabolic syndrome, proinflamatorycytokines},
}