@misc{Pizoń_Tomasz_Evaluation_2018, author={Pizoń, Tomasz}, address={Kraków}, howpublished={online}, year={2018}, school={Wydział Lekarski}, language={pol; eng}, abstract={The effectiveness of treatment of hypertension is low. The guidelines can be supplemented with "pathophysiological approach" to an individualized therapy.The objectives:-examination of the relationship between plasma renin activity (PRA), aldosterone and asymptomatic organ damage (AOD)-exploring the effect of antihypertensive treatment, consistent with Laragh and Alderman hypothesis, on blood pressure and AOD-evaluation of clinical and biochemical discrepancies among patients from low-renin and high-renin groups with particular reference to the values of serum lipidsOperating range: a planned prospective trial that included a total of 95-122 patients with first or second-degree hypertension.Conclusions:-the study of the effect of the renin-angiotensin-aldosterone system (RAAS) on the occurrence of AOD should include the relationship between the concentration of aldosterone and renin-PRA as the only indicator has no predictive value for the occurrence of AOD, on the other hand an aldosterone-to-renin ratio (ARR) does have it-the choice of antihypertensive drug based on PRA does not determine either the magnitude of the blood pressure reduction nor thesignificance of the AOD regression-patients with high-renin hypertension are characterized by higher serum total cholesterol and LDL-cholesterol, but the relationship between LDL-cholesterol and PRA is only in the low-renin group.}, title={Evaluation of the usefulness of plasma renin activity determination in the selection of optimal antihypertensive therapy among patients with primary hypertension according to the Laragh and Alderman concept}, type={Praca doktorska}, keywords={renin-angiotensin-aldosterone system, plasma renin activity, serum lipids, arterial hypertension, asymptomatic organ damage}, }