@misc{Słapińska_Magdalena_The_2017,
 author={Słapińska, Magdalena},
 address={Kraków},
 howpublished={online},
 year={2017},
 school={Wydział Lekarski},
 language={pol},
 abstract={The diagnosis and treatment of asthma is a significant problem of public health. Among the triggers of bronchial hyperreactivity, oxidative stress appears to play a vital role. Therefore, it was justified to undertake research into the mechanisms and the functional role of oxidative stress in the bronchi in a model of bronchial hyperreactivity. Towards this end, an experimental model of asthma was created using Dunkin Hartley guinea pigs. In a series of experiments, segments of the animals’ superior and medial lobar bronchi were exposed to: acetylocholine, histamine, MnTBAP (“scavenger” of free radicals) and DETC. Bronchial hyperreactivity was tested using an organ bath. The parameters of oxidative stress were assessed through the measurement of superoxide radical anion (O2-.) production in the bronchial segments using chemiluminescence. The results indicate a significant role of non-specific reactions in the occurrence of bronchospasm, which confirms the complex pathophysiology of bronchial hyperreactivity.},
 title={The mechanisms and the role of oxidative stress in the bronchial wall in a model of asthma and bronchial hyperreactivity},
 type={Praca doktorska},
 keywords={bronchial hyperreactivity, free radicals, oxidative stress, ovalbumin, asthma},
}