@misc{Wasik_Anna_Evaluation_2017,
 author={Wasik, Anna},
 address={Kraków},
 howpublished={online},
 year={2017},
 school={Wydział Farmaceutyczny},
 language={pol},
 abstract={Dissertation presents findings of pharmacological in vitro and in vivo studies evaluating psychotropic activity of 7 differently substituted indole derivatives. The other aim of this study was the attempt to clarify mechanism of their potential central activity, especially for ADN-2013. Aripiprazole was used as a reference atypical antipsychotic drug.In pharmacological studies in vitro, monoaminergic receptor binding profile and functional activity have been determined toward receptors D2, D3, 5-HT1A, 5-HT2A, 5-HT6, 5-HT7, α1, M and other binding sites e.g. SERT, hERG. In order to verify potential antipsychotic and cataleptogenic activity– the locomotor hyperactivity induced by D-amphetamine and MK-801 and the bar test, respectively, in mice, antidepressant activity – the forced swim test in mice and rats and the tail suspension test in mice, anxiolytic activity– the four-plate and marble burying tests in mice as well as the conflict drinking Vogel and the elevated plus-maze tests in rats were performed. Moreover, a mutagenic activity in vitro and an anorectic effect in vivo have been studied for ADN-2013. The specificity of each effect has been confirmed by appropriate control tests.The results of pharmacological studies presented confirm the desirability of searching for compounds with a multi-receptor profile of activity. ADN-2013 has been selected as a lead structure for fu},
 abstract={rther research focusing on the search for more effective and safer drugs that can be used in therapy of behavioural and psychological symptoms of dementia.},
 title={Evaluation of psychotropic activity of selected indoleamine derivatives with multireceptor profile of action},
 type={Praca doktorska},
 keywords={animal models of anxiety, animal model of depression, antipsychotic activity, partial D2-receptor agonists},
}