@misc{Kucharz_Jakub_Selected_2014,
 author={Kucharz, Jakub},
 address={Kraków},
 howpublished={online},
 year={2014},
 school={Wydział Nauk o Zdrowiu},
 language={pol},
 abstract={This study sought to identify predictive factors for treatment outcomes in stage IV ccRCC patients treated with sunitnib malate. It was a retrospective study, with the sample consisting of twenty-five patients treated with sunitinib malate for metastatic ccRCC between 2009 and 2013 at the Department of Oncology of the University Hospital in Cracow. I assessed sunitinib malate effects on selected clinical and laboratory indicators by comparing pretreatment values with values observed during treatment. In the second part of the study I assessed the relationship between progression-free survival times and selected clinical, laboratory, and radiological factors. I found that predictive factors for progression-free survival times included sunitinib-malate-induced hypertension, hand-foot syndrome (both assessed after the first treatment cycle), in-treatment hypothyroidism, and partial response assessed in an imaging study after the second treatment cycle. A detailed comparison between differences in these parameters in patients who had disease progression at 12.6 months and those who were progression free was carried out. I observed higher prevalence of hypertension, hand-foot syndrome, hypothyroidism, and myelotoxycity (lower neutrophil count) in the group without disease progression at the end of the studied period.},
 title={Selected clinical and laboratory parameters and treatment outcomes in patients with metastatic clear cell renal cell carcinoma (ccRCC) undergoing sunitinib malate therapy},
 type={Praca doktorska},
 keywords={renal, predictive factors, sunitinib, carcinoma},
}