@misc{Sierżęga_Marek_Prognostic_2005,
 author={Sierżęga, Marek},
 address={Kraków},
 howpublished={online},
 year={2005},
 school={Wydział Lekarski},
 language={pol},
 abstract={The aim of this study was to analyse clinical and molecular prognostics factors in resettable pancreatic cancer. One hundred and sixty-five patients underwent pancreatic resections between 1975 and 2004, including 103 (62%) males and 62 (38%) females (mean age 60.4 ±8.7 years). Of 101 tumours subjected to immunohistochemical tests, positive staining was identified for the following proteins: p53 - 71 %; Bcl-2 - 31 %; Bax - 90%; Bel-X - 79%; Bak - 25%. The presence of p53 was associated with poorer differentiation and a higher stage of the primary tumour. Bel-2 protein was related to lower staging, absence of lymph node metastases, and a higher proportion of tumours limited to the pancreas. No statistically significant correlations could be identified for Bel-X, Bax and Bak immunoreactivity and various parameters of the tumour. The median survival was 14.8 months and the 5-year survival was 14.3%. Of all analysed proteins, expression of p53 and Bel-X significantly correlated with poor survival. The following independent negative prognostic factors were identified with the Cox proportional hazards model: moderate or poor differentiation (G2/G3), metastases to regional lymph nodes, the percentage of metastatic lymph nodes > 15%, blood vessels involvement, infiltration of superior mesenteric artery or coeliac trunk, and microscopic or macroscopic residual tumour.},
 title={Prognostic factors in resectable pancreatic cancer : clinical and molecular variables affecting long-term survival},
 type={Praca doktorska},
 keywords={prognostic factors, pancreatic cancer, p53 protein, Bcl-2 proteins},
}