@misc{Chyrchel_Michał_Influence_2006,
 author={Chyrchel, Michał},
 address={Kraków},
 howpublished={online},
 year={2006},
 school={Wydział Lekarski},
 language={pol},
 abstract={Background Endothelial inflammatory activation is associated with profound impairment in vasodilator endothelial function. The aim of the study was to analyze the impact of short-term anti-inflammatory therapy with high dose statin and cycklooxygenase-2 (COX-2) inhibitor on endothelial function in patients with non ST segment elevation Acute Coronary Syndromes - NSTE ACS. Methods In 30 pts with NSTE ACS and elevated C reactive protein level endothelial function was assessed by coronary Acetylcholine (Ach) test within non-culprit vessel. Quantitative coronary angiography was done at baseline and after maximum dose of Ach. Vessel response was calculated as a percent change of mean lumen diameter (% change of Mean Lumen Diameter (LD)). Then pts were randomized to three groups: A (n=11) placebo, B (n=11) 80 mg atorvastatin, C (n=8) 80 mg atorvastatin and 25 mg rofecoxib. After 7 days of therapy control test was done within the same indicatory segments. Recovery of endothelial function was calculated as difference (delta) in % changes of Mean LD between day 1 and day 7. Results At day 1 significant decrease in Mean LD between baseline and the highest dose of Ach was observed in all groups: -20 % (group A), -25 % (B) and -26 % (C). After 7 days of therapy these changes averaged -21 % (A), -15 % (B) and -10 % (C). Differences between day 1 and day 7 were -1% (A), +10 % (B), +16 % in C},
 abstract={. Significant improvement of endothelial function was observed in group C. Conclusions NSTE ACS is associated with profound endothelial dysfunction. Short term therapy with 80 mg of atorvastatin and COX-2 inhibitor significantly improved endothelial function.},
 title={Influence of anti-inflammatory therapy on endothelial function in unstable angina},
 type={Praca doktorska},
 keywords={statins, inflammation, coxibs, endothelial function, acute coronary syndrome},
}