@misc{Grzywacz-Kisielewska_Agata_Evaluation_2017,
 author={Grzywacz-Kisielewska, Agata},
 address={Kraków},
 howpublished={online},
 year={2017},
 school={Wydział Farmaceutyczny},
 language={pol; eng},
 abstract={The inflammation, which is a response of tissuesto damaging agents is a natural adaptive process in thehuman body. However, chronic inflammatory process canbe associated with the pathogenesis of cardiovasculardisease, cancer and metabolic syndrome.The purpose of this research aims to determinedpotential anti-inflammatory properties of biomass extractsfrom in vitro cultures of selected edible mushrooms:Imleria badia − bay bolete, Cantharellus cibarius − goldenchanterelle and Agaricus bisporus − white bottommushroom. These popular mushroom species are a richsource of phenolic and indole compounds, unsaturated fattyacids and bioelements with anti-inflammatory activity.To investigate the anti-inflammatory effect of the testedextracts several cell lines: RAW 264.7, A549 and CaCo-2were used. The effects of mushroom extracts on theexpression of inflammatory markers, such ascyclooxygenase-2 (COX-2), prostaglandin E (cPGES),glutathione S-transferase (GSTM1), FP-receptor protein,interleukin-6 (IL-6), and transcriptional factors PPARγ,NF-ĸB and Nrf2 were analyzed.The tested extracts showed anti-inflammatory activityin the used in vitro models. Received results showedsignificant inhibition of inflammatory markers caused bytested extracts from I. badia, C. cibarius and A. bisporusand also a stimulatory effect on the nuclear factor Nrf2-dependent detoxification processes. Additionally, obtai},
 abstract={nedresults showed the importance of zinc and α-linolenic acidduring inflammatory processes in tested cell lines.},
 title={Evaluation of anti-inflammatory activity of extracts fromselected species of edible mushrooms and their biomass usingmolecular biology techniques},
 type={Praca doktorska},
 keywords={anti-inflammatory activity, Cantharellus cibarius, Imleria badia, Agaricus bisporus, zinc},
}