Search for: [Abstract cont. = "Sixty\-three percent, 21% and 14% of the subjects were affected, respectively, by middle differentiation grade \(G2\), high differentiation grade \(G1\) and low differentiation grade \(G3\) carcinomas. In 40,4% of cases mucinous adenocarcinoma cells were identified. Results\: Similar to other published papers in medical literature, mean plasma ghrelin concentration decreased statistically significantly after 60 and 120 minute in the postprandial period both in male and female control group \(respectively p=0.001 and p=0.01\; p<0.001 and p<0.001\). It proves the proper selection of the control group and correctness of the study protocol. In contrast to the control and male CRC group there was no statistically significant decrease in ghrelin concentration among female patients \(p=0.08\). Furthermore, there was a statistically significant increase in postoperative fasting ghrelin concentration among female patients \(p=0.01\), what was not observed in CRC male group \(p=0.2\). Mean fasting plasma ghrelin concentration in healthy female control group was statistically significantly increased in comparison to CRC female group \(p=0.048\). Mean fasting plasma ghrelin concentration in healthy male control group was lower in comparison to CRC male group, but the difference was not statistically significant. As expected, comparison of patients based on gender and body mass index \(BMI\), according to WHO calculation, showed lower mean fasting and postprandial plasma ghrelin concentration among overweight and obese patients \(BMI >25 kg\/m2\), but the differences were not statistically significant. Mean plasma ghrelin concentration fell statistically significantly after 120 minutes postprandialy in CRC male group with normal weight \(BMI 18.5\-24.9 kg\/m2\) \(p=0.04\). Due to small number of subjects in CRC overweight\/obese male group no statistically significant decrease of postprandial mean plasma ghrelin concentration was noticed \(p=0.27\). Among CRC female group with normal weight and overweight\/obese group there was no statistically significantly decrease in postprandial mean plasma ghrelin concentration \(p=0.85\). There were no differences in mean fasting plasma ghrelin concentration between subgroups divided based on location of CRC. Making comparison in terms of gender, statistically significantly lower level of plasma ghrelin among CRC female group than in male CRC group in colon was observed. Furthermore, there was no statistically significantly difference in mean fasting plasma ghrelin concentration in subgroups divided in respect of invasion grade pT \(p=0.53\), presence of lymph nodes metastasis pN \(p=0.95\), differentiation grade \(p=0.36\), Dukes, Astler\-Coller staging \(p=0.96\), presence of mucinous adenocarcinoma cells \(p=0.6\) and type of performed operation \(p=0.33\). Age, weight \(in contrast to the healthy control group\), height, total lymphocyte count, plasma albumin and protein concentration and preoperative CEA level was found to be not correlated with the fasting ghrelin concentrations. ROC curve analysis showed that fasting plasma ghrelin concentration can be useful in risk assessment of colorectal cancer disease with cut\-off point ≤18.43 pg\/ml \(sensitivity 37.5%, specificity 95.2%\; likelihood ratio 7.87\) in female group. ROC curve analysis showed that changes in postprandial plasma ghrelin concentration can be useful in risk assessment of colorectal cancer disease with cut\-off point ≤ 1.68 pg\/ml \(sensitivity 86.7%, specificity 85.7%\; likelihood ratio 6.1\) in female group. Conclusion\: Ghrelin could be one of the primary risk factors of developing colorectal cancer in female because of the confirmation statistically significant difference in fasting and postprandial plasma ghrelin level between healthy control and CRC female group. The lack of difference in plasma ghrelin concentration between various stages and cell differentiation grade of CRC suggests that ghrelin exerts its activity in the early period of CRC carcinogenesis. Furthermore, the prog"]

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