Search for: [Abstract = "ysis revealed that significant predictors of diabetic retinopathy were\: age at diagnosis of diabetes, duration of diabetes, HbA1c level, never\-smoking status, urea serum level. The alleles and genotypes of examined markers were not associated with DR in T2DM group in non\-stratified analysis. To investigate the impact of T2DM duration on development of DR, we performed additional analysis that excluded short duration DR subjects \(below 50th percentile\) and long\-duration DR subjects \(above 75th percentile\), DR group\: 88 individuals, mean diabetes duration 11.4±5.3 yrs, NDR\: 136 individuals, mean disease duration 13.2 yrs ± 6.2, respectively. This analysis suggested that the alanine variant of Pro12Ala might be associated with decreased risk of DR \(p=0.026 for alleles, p=0.04 and p=0.014 for genotypes in additive and dominant models, respectively\). Conclusions\: The prevalence of diabetic retinopathy was 33.7% in examined populations. We were able to confirm the role of some clinical risk factors in the pathogenesis of DR\: age at diagnosis of diabetes, duration of the disease, HbA1c level, never\-smoking status, urea serum level. Our data suggests that the alanine variant of the Pro12Ala polymorphism of PPAR\[gamma\] might be associated with decreased risk of DR in T2DM. This effect may be of indirect nature, at least in part, due to diabetic kidney disease."]

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