Search for: [Abstract = "y chronic magnesium treatment. Furthermore, magnesium administration in stressed rats led to the increase level of GluN28 subunit of NMDA receptor and PSD\-95, compare to control stress animals. Removal of olfactory bulbs induced a decreased level of GAD\-67 in PFC and reduced level of P\-S845 of GluA 1 subunit of AMPA receptors in the hippocampus. Chronic administration of magnesium at a dose of 15mgMg\/kg reversed these changes. Two weeks of magnesium treatment in OB rats led to enhanced P\-S831 and P\-S845 of GluA 1 subunit of AMPA receptors in PFC, compare to 08 rats treated by NaCI. Concomitantly the BDNF level in PFC after magnesium treatment was also increased compare to 0B Nacl rats. The enhanced expression of BDNF after magnesium treatment in OB rats was also noticed in amygdala and hippocampus. In amygdala of 0B rats chronically treated with magnesium also elevated level of GluN2B subunit of NMDA receptors was found. In PFC of 0B animals decreased levels of mRNA of MT 1, 2 and 3 were observed. Chronic magnesium treatment normalized level of mRNA of MT 1 and MT 2. The results obtained in this PhD thesis provide further, preclinical evidence for the antidepressant\-like activity of magnesium. Antidepressant\-like activity of magnesium showed in two animal model of depression is very important argument for potential utility of magnesium in treatment of clinical depression. Addit"]

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