Search for: [Abstract = "vivo. In order to verify potential antipsychotic and cataleptogenic activity \(PZ\-395, PZ\-511, PZ\-508, PZ\-549 and PZ\-599\)  the locomotor hyperactivity induced by D\-amphetamine and\/or MK\-801 was performed and the bar test, respectively, in mice\; antidepressant activity \(PZ\-395, PZ\-397, PZ\-493, PZ\-510, PZ\-511, PZ\-380, PZ\-387, PZ\-508, PZ\-549 and PZ\-599\)  the forced swim test in mice, anxiolytic activity \(the four plates test in mice, the burying test in mice, the conflict drinking Vogel test in rats, the elevated plus maze test in rats\). The specificity of each effect has been confirmed by appropriate control tests. \; It has been shown that the tested molecules are characterized by a significant affinity for the 5\-HT1A, 5\-HT2A, 5\-HT7 and D2 receptors. Monochlorophenylpiperazine derivatives seem to be\: 5\-HT2A\/D2 antagonists \(PZ\-397, PZ\-493 and PZ\-510\), compound PZ\-395 \- an antagonist of 5\-HT1A\/5\-HT2A\/5\-HT7\/D2 receptors, and a derivative PZ\-511  an antagonist of 5\-HT2A\/5\-HT7\/D2 ones. Among derivatives of 2,3\-dichlorophenylpiperazine PZ\-387, PZ\-549 and PZ\-599 have been found as partial receptor agonists of D2\/5\-HT2A and postsynaptic 5\-HT1A antagonist, PZ\-508  a partial agonist of D2 and 5\-HT1A\/5\-HT2A antagonist and PZ\-380  a partial agonist of D2\/5\-HT2A antagonist.In vivo experiments indicate that from the series of monochlorophenylpiperazine derivatives, a compound PZ\-511 produ"]

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