Search for: [Abstract = "ve analysis showed that fasting plasma ghrelin concentration can be useful in risk assessment of colorectal cancer disease with cut\-off point ≤18.43 pg\/ml \(sensitivity 37.5%, specificity 95.2%\; likelihood ratio 7.87\) in female group. ROC curve analysis showed that changes in postprandial plasma ghrelin concentration can be useful in risk assessment of colorectal cancer disease with cut\-off point ≤ 1.68 pg\/ml \(sensitivity 86.7%, specificity 85.7%\; likelihood ratio 6.1\) in female group. Conclusion\: Ghrelin could be one of the primary risk factors of developing colorectal cancer in female because of the confirmation statistically significant difference in fasting and postprandial plasma ghrelin level between healthy control and CRC female group. The lack of difference in plasma ghrelin concentration between various stages and cell differentiation grade of CRC suggests that ghrelin exerts its activity in the early period of CRC carcinogenesis. Furthermore, the progression of the disease disturbs the correlation between BMI and plasma ghrelin level, which was observed in healthy control group. Radical resection of the CRC has no influence on plasma ghrelin level what, in turn, negates influence of the tumor alone on observed changes. However, identified changes in plasma ghrelin concentration among female with CRC may be used to assess risk of developing CRC in"]

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