Search for: [Abstract = "ut also epigenetics, currently defined by numerous processes related to the control of gene expression as a result of modification of genetic material, not related to changes in the sequence of nucleotides in DNA, such as a change in the level of DNA methylation. Recently, there have been more and more reports about epigenetic factors conditioning the development of diabetes and its chronic complications. The association of a different metDNA profile with nerve fiber degeneration has been described in patients with T2DM and diabetic peripheral neuropathy. It should be noted that the previous works mainly concern T2DM. However, there is no information on the influence of the above epigenetic mechanisms on the development of neuropathy, and in particular CAN in patients with T1DM. Considering many questions and doubts about the mechanisms of \"metabolic memory\" leading to the development and progression of chronic organ complications\; the aim of this study was to test the hypothesis whether epigenetic mechanisms have an impact on the development of autonomic diabetic neuropathy of the cardiovascular system in patients with T1DM. OBJECTIVES The general objective of the doctoral dissertation was to test the hypothesis whether selected epigenetic mechanisms have an impact on the development of autonomic diabetic neuropathy of the cardiovascular system in patient"]

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