Search for: [Abstract = "uman cells including normal peripheral lymphocytes such as T, B, and NK \(natural killer\) cells. RCAS1 inhibits growth of receptor expressing cells in vitro and in vivo and induces apoptotic cell death through activation of caspase 3 and caspase 8 and collapse of mitochondria\! transmembrane potential. Thus, it facilitates escape from host immune surveillance by inducing apoptosis of activated CD3\+ and NK cells and enables the disease to spread. High RCAS1 expression in many examined cancer was connected with high TIL apoptosis rate, and was related to poor prognosis in these cases. The aim of his work was to determine RCAS1 expression in pharyngeal and laryngeal cancers and non\-cancerous tissue samples \(histological elear surgical margin, chronic inflammation\), analyze the expression with respect to the clinicopathological features of the tumor \(TNM, grading\) in order to evaluate its possible prognostic value in cancer. Materials and Methods All patients with pharyngeal and laryngeal cancer in this study had undergone surgery between January 2002 and December 2003 at the Department of Otolaryngology and Head and Neck Surgery of Jagiellonian University in Krakow. In all cases patient's agreement was received. The approval for the research program was obtained from the Ethical Committee of the Jagiellonian University in Krakow\: KBET\/379\/13\/2002. The patients"]
