Search for: [Abstract = "ttained using capsaicin at total dose of 100 mg\/kg given s.c. 10 days before the tests. To assess the effects of CCK, \- receptor blockade on pancreatic secretory response to melatonin, L\-tryptophan, leptin or ghrelin CCK, receptor antagonist was used. The concentration of α\-amylase was measured in collected samples of pancreato\- biliary juice. The results were expressed as total α\-amylase output \(IU\/L\/15 min\). Plasma CCK level was estimated by radioimmunoassay method \(RIA\). The blood samples were taken at the end of the experiment from the abdominal vena cava and the blood was withdrawn into EDTA containing polyethylene tubes. The results of the study shows that exogenous melatonin, melatonin precursor L\-tryptophan, leptin or ghrelin given into the duodenal lumen are able to pancreatic enzyme secretion under basal conditions or following the stimulation with diversion of pancreato\-biliary juice. Bilateral vagotomy, deactivation of sensory nerves with capsaicin as well as CCK1 receptor blockade completely reversed the stimulatory effects of examined substances on pancreatic exocrine secretion. Intraduodenal application of melatonin, L\-tryptophan, leptin or ghrelin manifested in dose\-dependent increase of plasma CCK concentration. I conclude that exogenous melatonin, its precursor L\-tryptophan, leptin or ghrelin administered intraduodenally could take a part in the physiologic"]

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