Search for: [Abstract = "ts, induced increased expression of cp1a1 gene, which encoded a cytochrome P450 involved in phase I xenobiotic biotransformation. Interestingly, PM2.5 collected away from the busy road was more bioreactive, as it also up\-regulated 10 genes encoding proteins associated with inflammation and apoptosis\: transcription factor NFκB, interleukins \(IL\-1α, IL\-1β\), protein p21, factor CDK, and 5 heat shock proteins HSP. While the organic fraction of the sample caused increased expression of genes encoding XRCC2 protein, which is involved in the repair of damaged DNA, inducible nitric oxide synthase \(iNOS\) and tumor necrosis factor α \(TNF\-α\). The large difference in bioreactivity of PM2.5 collected at sites remote from each other only 1 km most probably stemmed from the different inorganic compositions, as the analysis of PAHs in both samples did not show significant differences in the content of individual hydrocarbons. Elements absent or present in trace quantities in the air near a busy road in the first collection period were P, Zn and Fe. In particular, transition metals such as Fe and Zn may have contributed to the formation of free radicals and promoted inflammation. \; No increase in the expression of any of the analyzed genes was detected in endothelial cells exposed to PM2.5 collected near a busy road at concentration of 15 μg\/cm2. In contrast, the organic fraction obtained from"]
