Search for: [Abstract = "tly described the gastroprotective role of ghrelin. Both intravenous or intracerebroventricular administration of ghrelin to the anaesthetized rats were reported to stimulate gastric acid secretion and motility . This effect has been reversed by vagotomy or atropine pretreatment, suggesting that ghrelin affects gastric function via the activation of the vagus nerve and muscarinic receptors. Recent studies have also demonstrated that ghrelin exerts the gastroprotective actions in the stomach against to stress\-induced damage. Ghrelin has been also shown to modulate endocrine as well as exocrine pancreatic secretions, but the physiological role of this peptide in the modulation of pancreatic function remains unclear. It has been shown that ghrelin given intravenously is able to inhibit pancreatic exocrine secretion stimulated by cholecystokinin \(CCK\) in anaesthetized rats. This inhibitory effect of ghrelin on pancreatic enzyme secretion has been also observed in vitro, in pancreatic lobules. On the other hand central administration of ghrelin stimulated pancreatic exocrine secretion in conscious rats. Both gastric and pancreatic effects of ghrelin lune been shown to be mediated via vagus\-dependent cholinergic pathway and probably via sensory nerves. The aim of my study was to evaluate the role of exogenous melatonin, melatonin precursor, L\-tryptophan, leptin or ghrelin administer"]

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