Szukana fraza: [Abstrakt = "tity of Fomitopsis officinalis species obtained from in vitro cultures, qRT–PCR – to measure the level of mRNA expression in mouse hippocampus after long–term dietary supplementation with lyophilized material, Western Blot – to measure the level of proteins in RAW 264.7 murine macrophage cells and rat hippocampus after chronic administration of 3 different doses \(100 mg\/kg, 250 mg\/kg, 500 mg\/kg\) of the material\; 4\) an artificial digestive system Gastroel 2014 – to study the bioavailability of organic compounds and bioelements\; 5\) in vivo studies\: elevated plus maze \(EPM\) and open field tests – to assess an anxiolytic–like effect in rodents, forced swimming test \(FST\) – to profile stress coping strategies in rats, novel object recognition test \(NOR\) – to test long–term memory of mice, and the attentional set– shifting test \(ASST\) – to test executive functions of rats. In vivo studies were performed on male CD1 mice and Wistar rats, i.e. on outbred strains. Animals' diet was supplemented with 2 mg \(mice\) or 5 mg \(rats\) of lyophilisate per 1 g of chow, in order to allometrically adjust the daily dose in rodents to a commercially available preparation of another medicinal mushroom – the lion's mane. For this reason, in studies on dietary supplementation, lyophilisate of this species was used as positive control. In addition, both species were compared to t"]
