Search for: [Abstract = "tions in the whole group equalled to 84.3%, 37.8% and 23.0%, respectively\). The proportion of cyclophosphamide use during the maintenance treatment was significantly lower in the cases with diagnosis established after 2010, compared to those with diagnosis made before 2004 or between 2004 and 2010 years \(5.7% vs. 26.09%, p<0.01 and 5.7% vs. 15.9%, p<0.01, respectively\). The median cumulative dose of cyclophosphamide equalled 7.99g \(4.18\-14.0\). Renal replacement therapy was required in 21.9% of all AAV cases. MPA patients predominated among patients requiring dialysis \(MPA vs. GPA \- 44.3% vs. 21.5%, p<0.01\). None of EGPA patients needed renal replacement therapy. The most common adverse effect of immunosuppressive treatment were infections – proportion of cases equalled 38.8% of the whole group. The infections' occurrence was associated with longer average observation time \(OR=1.05, 95% CI 1.00\-1.10, p=0.03\), GCS pulses administration \(OR=2.83, 95% CI 1.73\-4.64, p<0.01\) and renal replacement therapy \(OR=1.725, 95% CI 1.10\-2.71, p=0.02\). The analysis, regarding Polish population of AAV with respiratory involvement was performed in the second part of the study. The prevalence of respiratory involvement \(with radiological confirmation\) amounted to 68.5% of all AAV cases, 97.6% of EGPA cases, 67.8% of GPA cases and 40.0% of MPA cases. Constitutional symptoms, ENT, ca"]

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