Search for: [Abstract = "ties and reversed scopolamine\-induced cognitive deficits in rodents. Bearing the above in mind, this study aimed to discover the cellular mechanisms responsible for the antidepressant\-like and procognitive activity of HBK\-15, as well as to determine how the compound affects various types of memory and phases of memory formation. First, the affinity of HBK\-15 to serotonin, dopamine, histamine, muscarinic, metabotropic, and ionotropic glutamate receptors as well as to dopamine, GABA and noradrenaline transporters was assessed to get a full receptor profile of the tested compound. Next, several rodent behavioral tests were used to investigate whether HBK\-15 can reverse MK\-801\- induced deficits of various types of memory \(recognition, emotional, motor, and spatial\) at different stages of the learning processes \(acquisition, consolidation, retrieval\). Moreover, this study investigated the effect of a single administration of HBK\-15 on the level of several neurotransmitters, including serotonin, dopamine, noradrenaline, acetylcholine, glutamate, gamma\-aminobutyric acid, and histamine. The next research aim was to assess the antidepressant\-like and procognitive activity of HBK\-15 after a single administration in the unpredictable chronic mild stress model, as well as how long these pharmacological effects lasted. Furthermore, the explanation of the mechanism of action"]

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