Search for: [Abstract = "thmatics we found higher numbers of apoptotic lymphocytes in cultures with DEX. The percentage of CD4\/CD25high was also increased in this group. Conclusions\: The decreased sensitivity to GCS in severe and refractory asthma is not the consequence of impaired expression of GR isoforms, and does not result from abnormal T\-cell reactivity. The elevated expression of CD40L may be the reason of the weaker reactivity to GCS observed in vivo. The induction of peripheral Treg CD4\/CD25high pool in severe steroid dependent asthma is not disturbed and constitutes one of the most efficient mechanisms that is necessary to achieve good asthma control."]

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