Search for: [Abstract = "the PM2.5 up\-regulated genes involved in repair of damaged endothelial cells\: fibronectin 1 \(FN1\) receptor 2 vascular endothelial growth factor \(VEGFR\-2\), von Willebrand factor, and metalloproteinase 2 \(MMP\-2\). These findings were suggestive of a low\-grade cell injury, as 4 hours after dosing mainly genes responsible for vascular endothelium repair were detected. A similar response was observed in case of ZnO NPs at a concentration of 5 μg\/cm2, which up\-regulated FN1, cell adhesion molecule ICAM\-1, ADAM17 glycoprotein, which stimulated the release of L\-selectin and TNFAPI3 protein involved in the reduction of inflammation.The degree of cytotoxicity of individual NPs depended on both the NP type and the used test. The most toxic to vascular endothelial cells, ZnO NPs induced a dose dependent decrease in cell viability and motility. In case of CB NPs and amorphous form of SiO2 no significant apoptosis was detected\; although a significant decrease in cell proliferation in the following days of exposure was observed. The disturbance of proper endothelial function was probable due to accumulation of NPs inside cells. Ni and ZnO NPs with positive zeta potential caused the highest percentage of damage to plasmid DNA, whereas both forms of negatively charged SiO2 NPs elicited minimal bioreactivity. Interestingly, ZnO NPs exerted DNA damage at one hundred times lower dose than the other"]
