Search for: [Abstract = "that, apart from drugs as gold salts, sulphasalazine, corticosteroids, there are medicines that interfere with immune processes. These include cyclosporine A, antibodies that neutralize TNF\-α or IL\-1R antagonists. However, most of these inhibit immune response non\-specifically and cause many side effects. For many years there have been numerous efforts to create a vaccine that can protect from autoimmune diseases including RA. One possible method relies on the induction of oral tolerance. In an animal model it was shown that feeding with collagen induced strong tolerance in the periphery, resulting in significantly reduced symptoms of CIA. Similar observations were also made in experimental autoimmune encephalomyelitis \(EAE\), another autoimmune disease mediated by Th1\/Th17 lymphocytes. However, clinical trials in humans showed no benefit in RA or multiple sclerosis patients fed with collagen or myelin basic protein, respectively. Although skin is considered to be an organ where immune responses are easily induced, little attention has been given to skin induced tolerance. Wang, et. al. showed that epicutaneous \(EC\) application of the protein antigen OVA resulted in allergic dermatitis accompanied by the appearance of IL\-4 secreting cells. In addition, Herrick, et al. showed that EC immunization with protein antigen induced a Th2\-mediated animal model of asthma. These data m"]

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