Search for: [Abstract = "tal, epigenetic and genetic factors affecting the development of melanoma. In addition, for the first time in history, epigenetic age was characterized using different biological clocks based on DNA methylation, as well as age acceleration of patients diagnosed with malignant melanoma compared to the healthy population was determined. Material and methods. The study was conducted in a group of 202 patients \(research group \- 101 people, control group \- 101 people\). Patients with newly or previously diagnosed malignant melanoma of the skin were included in the research group. All study participants were interviewed using an extensive interview questionnaire. Venous blood was collected from all participants and a buccal mucosa swab was performed twice. Genome DNA methylation and SNP \(Single Nucleotide Polymorphism\) analyses of all study subjects were performed using Illumina's microarray technology \(Infinium® Global Screening Array and Infinium® MethylationEPIC 850K, Illumina\). Based on the collected detailed questionnaire data, an analysis of correlations between environmental factors, methylation data, SNP data and the occurrence of malignant melanoma was carried out, as well as the epigenetic age of patients was determined using various types of biological clocks based on DNA methylation. Results. The risk of developing malignant melanoma was sig"]

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