Search for: [Abstract = "subsequent amelioration of disease. Moreover, skin induced suppression was found to effectively delay allogeneic graft rejection. Therefore, skin induced immune suppression may be a new therapeutic strategy to treat inflammatory disease. However, the lack of antigen specificity of skin induced tolerance gives rise to the risk that generalized immunosuppression might also inhibit helpful anti\-microbial responses. In contrast to the experimental models described above, where purified protein antigen applied alone to induce tolerance, adminitration of antigen along with pathogen associated molecular patterns \(PAMPs\) recognized by pattern recognition receptors \(PRRs\) e.g. TLR may play a crucial role not only in the induction of an immune response but also in overcoming tolerance. In this dissertation, the role of TLR ligands in reversing skin induced immune suppression is described. Experiments performed using a model of CS in CBA\/J mice showed that antigen non\-specific suppression induced via epicutaneous immunization with protein antigen could be reversed when animals were simultaneously immunized with protein antigen and PAMPs. As was shown skin induced contrasuppression could be achieved after epicutaneous immunization with protein antigen TNP\-Ig together with bacterial lysates \(Staphylococcus aureus, Staphylococcus epidermidis oraz Propionibacterium acnes\) or complete Freund’"]

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