Search for: [Abstract = "stabilization occurred at lower initial height \(32.7%\).Positive local results, which were defined as tumour growth inhibition with or without tumour size reduction, were observed in 130 patients \(76.0%\) treated with Ru\-106 brachytherapy and in 195 patients \(95.1%\) treated with I\-125 brachytherapy. Cox regression analysis revealed that the tumour regression type \(model II and III\), the apical height radiation dose \( 100 Gy\) and the patient’s age \( 40\) were the factors which significantly determined a positive result of the treatment.Local treatment failure, understood as a relapse or tumour growth in spite of the treatment, occurred in 40 patients \(23.4%\) treated with Ru\-106 isotope and in 9 patients \(4.4%\) treated with I\-125 isotope. Cox regression analysis showed that the radiation dose below 100 Gy applied to the top of the tumour and the epithelioid histopathological type of melanoma were the factors which significantly increased the risk of tumour relapse. The study of factors affecting the primary lack of response to the treatment revealed adverse impact of the type of applicator \(Ru\-106\), tumour location \(the front edge – rearwardly from the equator of the eye, the rear edge \- in close proximity to the optic nerve\), the apical height radiation dose \( 100 Gy\) and the base diameter of the tumour \( 10 mm\).During the entire time of the study tumour metastases were found in 25 patients \(14.6%\) treated with Ru\-106 therapy and in 31 patients \(15.1%\) treated with I\-125 therapy. The most common site of metastases was the liver \(89.3%\). Less frequent sites included the lungs, brain, skin, pancreas, adrenal glands, spinal cord, spleen and ureter. Cox proportional hazards model revealed the correlation between the type of tumour regression \(model I\), retinal detachment, the location of the rear edge of the tumour rearwardly from the equator of the eyeball, and the occurrence of metastases.During the whole period of observation the enucleation procedure was performed in 47 patients \(12.5%\), including 24 \(14%\) treated with Ru\-106 isotope and 23 \(11.2%\) treated with I\-125 isotope. In 95.8% of the patients treated with Ru\-106 brachytherapy the indication for removal of the eyeball was a relapse and the primary lack of treatment response, whereas in the group treated with I\-125 isotope the main indication for surgery constituted postradiation complications \(78.3%\). Cox analysis demonstrated a significant correspondence between the type of tumour regression \(model I\), presence of relapse, mushroom tumour shape, and the risk of secondary loss of the eye."]