Search for: [Abstract = "social value of early\-phase oncology trials involving pediatric population, and to evaluate aspects of research waste in selected clinical trials, done in pediatric population. Another aim is to develop criteria which will help in the prospective assessment of social value provided by selected types of clinical trials. Methods\: The following dissertation consists of meta\-research and theoretical analysis articles. The former are based on the systematic review methodology, and provide data on social value and research waste in clinical trials. The meta\-study of social value looked at pediatric phase 1 studies. The cross\-sectional analysis assessed an aspect of research waste, i.e. insufficient publication of results. This study looked at trials registered on the ClinicalTrials.gov platform, associated with at least one Polish academic medical center. The latter group of articles in the following dissertation are theoretical analyzes. They aim to summarize data from meta\-research, and develop criteria helpful in the prospective assessment of social value of selected clinical trials. Results\: The analysis of social value shows, that the treatments tested in 5% of analyzed studies are eventually approved by a regulatory agency for use in the tested indication. Our analysis also shows that more than 1\/3 of the treatments tested in phase 1 move on to further phases of clinical t"]

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