Search for: [Abstract = "s collected in 84 newborns. Of these neonates 27 were classified with LGA. In 92% of pregnancies, maternal HbA1C level was less than 6,1%. Mean 2nd and 3rd trimester 1,5\-AG concentration was significantly lower in women with LGA in comparison with pregnancies with normal\-weight newborns, and correlated significantly with birth weight. In a multivariate linear regression, 3rd trimester 1,5\-AG was the strongest predictor independently associated with the newborn weight after adjusting for the possible confounders \- week of birth, pre\-pregnancy BMI and maternal age \(p<1x10\-6\), and other glycemic control assessment methods\: HbA1c and SMBG indices. The unadjusted risk of 1,5\-AG for LGA was OR=0.34 \[95%CI\: 0.17\-0.65\; p<10\-4\], the risk of macrosomia was OR=0.17 \[95%CI\: 0.07\-0.47\; p=6x10\-4\]. When controlled for potential confounders, these findings persisted in the multivariate logistic regression as 3rd trimester 1,5\-AG appeared as a strong predictor for neonate birth weight \- its 1 µg\/ml increase was associated with a threefold decrease in the risk of LGA and more than fivefold decrease of macrosomia. Additional ROC analysis revealed a sufficient AUC and high sensitivity of this marker as a clinical predictor of neonate LGA and macrosomia. This dissertation project is the first large scale, systematic analysis of 1,5\-AG performance in monitoring metabolic control in pregnancy complic"]

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