Search for: [Abstract = "rtile\) showed high discriminatory power in identifying patients with prolonged clot lysis time. The second investigated factor was NETs, i.e. neutrophil extracellular traps. Four markers of NETs were assessed\: two nuclear markers, such as citrullinated histone H3 and cell\-free DNA, and two cellular markers, such as myeloperoxidase and neutrophil elastase. The concentration of nuclear markers was shown to associate with glucose concentration, glycated hemoglobin and interleukin 6. The concentration of cell\-free DNA was positively correlated with peak thrombin. Both citrullinated histone H3 and cell free DNA significantly contributed to the variance of clot lysis time and clot permeability. Moreover, myeloperoxidase concentration positively correlated with clot lysis time. The other predictors of clot lysis time were\: plasminogen activator inhibitor 1 concentration and concomitant cardiovascular disease, as well as time since diabetes diagnosis. The third investigated factor was α2\-antiplasmin incorporation into the clot. The prolonged clot lysis time in women with diabetes when compared to men with diabetes was shown to associate with enhanced α2\-antiplasmin incorporation into the clot. A model was developed to describe the relationship between the clot lysis time assessed according to Carter et al. and the extent of α2\-antiplasmin incorporation into the clot, plasminogen"]

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