Search for: [Abstract = "rperium \(170.0 ± 154.0 vs 384.0 ± 185.6 pg\/μmol creatinine\; p<0.0001\). There were no significant differences between the highest and the lowest quartile with respect to the prevalence of PlA2 allele, APS and the concentration of IL\-6 and sCD40L but in the 2nd trimester there was a significant difference with regard to CRP \(p=0.05\), tHcy \(p=0.05\), aCL IgG \(p=0.01\) and after puerperium with respect to aCL IgG \(p=0.01\). In women in the highest quartile the pregnancy was shorter \(p=0.03\). Intrauterine growth restriction and delivery of small for gestational age newborns \(p=0.05\) and fetal distress \(p=0.05\) were also more frequently observed in this subgroup. The 2nd trimester range of the highest quartile classified also 9 women in the 3rd trimester as resistant to ASA and only 3 women after puerperium. The analysis based on the RI value showed that women with a low response to ASA had higher urinary 11\-dTXB2 concentrations in the 2nd trimester \(64.35 ± 32.36 vs 443.67 ± 273.56 pg\/µmol creatinine, p<0.0001\) and the 3rd trimester \(77.65 ± 25.27 vs 492.62 ± 197.09 pg\/µmol creatinine\; p<0.0001\), tHcy in the 2nd trimester \(p=0.05\) and sCD40L in the 3rd trimester \(p=0., 05\) compared to women responsive to ASA. In the latter group the effect of ASA seen as a reduction in concentration of 11\-dTXB2 during the 2nd trimester was more profound during the 3rd trimester and weaker after puerper"]
