Search for: [Abstract = "rly gastric cancer is approximately 90%, were as in advanced stages five years survival rate declines to 10\-15%. There are probably numerous additional factors which can influence the prognosis in gastric cancer patients\: among them are changes in E\-cadherin\-catenin unit \(ECCU\) proteins. These proteins are normally responsible for the maintenance of intracellular adhesion in epithelial tissues and for providing signal transduction between epithelial cells. the aim of the study Status of the CDH I gene coding E\-cadherin protein and the expression of Ecadherin and B\-catenin proteins were investigated in the group of 84 sporadic, advanced gastric cancers. The correlations between E\-cadherin gene mutations, disturbances of immunohistochemical expression ofECCU proteins and histological features of neoplasm\: cancer differentiation, type of growth, presence and composition of inflammatory in fil tra te, angiogenesis, expression of p\-53 and survivin proteins and the survival interval after operation were investigated. materials and methods The materiał was collected from the patients operated for gastric cancer between 1996\-2000 in the First Surgical Department in Cracow. lt consisted of 84 advanced, sporadic gastric cancers. Basic histopathological techniques\: hematoxilin\-eosin and Alcian\-PAS staining as well as immunohistochemistry with specific, monoclonal antibodies and mo"]

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