Search for: [Abstract = "registered the forming of three hydrolysis products, one of which was identified as 2 \[amino\(carboxyl\)methyl\]\-5\-\{\[\(6\-hydroxy\-2\-methyl\-5\-oxo\-2,5\-dihydro\-I ,2,4\-triazine\-3\-yl\)sulfany l\]methy l \}\-3 ,6\-dihydro\-2H\-1,3\-diazine\-4\-carboxylic acid, the second one being probably an isomer of the compound identified, while the third one is a thiazole derivative. Based on the gained results of the decomposition reaction of 1\-acetoxyethyl ester of cefuroxime, cefaclor and ceftriaxone in the solutions, it was established that it proceeds according to first\-order reaction. The calculated values of t0.1 and t0.5, indicating decomposition time of the cephalosporins examined in solutions without any B\-cyclodextrine content are significantly smaller than the analogous parameters obtained for examinations with a B\-cyclodextrine content. This is confirmed with the thermodynamic values\: activation energies \(Ea\) and activation enthalpies \(\~H\+\+\) calculated for the solutions examined. It was found that decomposition rate for all the antibiotics included in the research programme depended both on acid concentration, temperature and on incubation time. The strongest influence of p\-cyclodextrine on the stability if the active substances was observed in the case of solutions of the antibiotic complexes with B\-cyclodextrine in the tablet form, additionally enriched with B\-cyclodextrine solution. Sma"]

Number of results: 1