Search for: [Abstract = "ransplanted animals. A characteristic pattern of body loss consisting of a fall to approximately 86% of initial body weight on day \+7 followed by return to the initial weight on days \+14 to \+17 and another decrease leading either to the death of the animal or to a long time plateau was observed in all allotransplanted mice. However, the average relative weight \(percentage of the initial body mass\) of C3\+\/\+ animals was constantly higher. Particularly, more dynamic increase of body weight of wild\-type animals was observed on days \+10 to \+17 \(average relative body weight of C3\+\/\+ mice was higher by 2,63%\; p=0,0001\). Interestingly, the body weight on day \+10 strongly correlated with overall survival \(p=0,002\). Skin changes tended to be less severe in wild type animals but statistically significant effect was detected only in the case of the skin of paws \(p=0,0007\). Analysis of peripheral blood revealed higher WBC \(by 3,31 x 103\/l\; p=0,0213\), higher number of CD3\+CD4\+ \(by 1,31 times\; p=0,0293\) and higher CD4\/CD8 ratio \(1,42 times\; p=0,0079\) in C3\-\/\-. Skin changes observed in histopathological examination on day \+16 were more intense in wild type allogeneic graft recipient mice. \; Observed differences in course of GvHD in C3\+\/\+ and C3\-\/\- mice, and foremost a better survival of wild type animals suggest that complement may have a beneficial role in ameliorating consequences of GVHD i"]

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