Search for: [Abstract = "pression of pro\- and anti\-inflammatory cytokines by lymph node cells isolated from treated mice was investigated. These experiments showed that EC immunization with COLL II does not affect production of IL\-4, IL\-6, IL\-10, IL\-17E, TGF\-β or IFN\-γ when compared to DPBS\-treated animals. However, production of IL\-17A and TNF\-α was significantly increased. In vivo neutralization of IL\-17 abolished EC induced protection from the disease, which correlated with increased MPO activity and upregulated production of anti\-COLL II IgG2a antibodies. In the final part of the study, it was shown that transfer of EC induced T regulatory cells either before or after induction of CIA suppressed disease. Moreover, EC treatment of mice with COLL II after first signs of CIA caused partial recovery from disease, suggesting that this method might be useful to treat ongoing disease. In Summary, induction of immune tolerance via EC immunization could potentially be used to prevent and possibly treat RA and other autoimmune disorders. The noninvasive application of protein antigen to the skin and the ability to induce antigen nonspecific T regulatory cells makes EC immunization an attractive potential therapy."]

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