Search for: [Abstract = "part of hair follicles and expression of type 7, 8 and 9 TLRs in the lymphocytic infiltrate in the dermis. Patients with CLE showed statistically significantly lower strength of expression of type 9 TLR in the epidermis, lesser thickness of the epidermis with positive expression of type 8, 9 TLRs, and a lower average percentage of lymphocytes with positive expression of type 8, 9 TLRs compared to the control group. Moreover, patients with SCLE showed significantly higher expression of type 8 TLR in the epidermis compared to patients with DLE. On the other hand, in patients with DLE, a significantly higher expression of type 9 TLR in the epidermis and epithelial part of hair follicles was observed compared to patients with SCLE. The strength of type 9 TLR expression in lymphocytes in patients with subacute and discoid lupus erythematosus correlated with the response to treatment with hydroxychloroquine and the percentage reduction in CLASI index after treatment. Patients with the best response to treatment \(decrease in CLASI after treatment above 80%\) showed the highest level of type 9 TLR expression in lymphocytes \(grade 3 on a 0\-3 scale\). Moreover, patients whose dose of hydroxychloroquine was up\-titrated to 400 mg, due to an insufficient response to treatment with hydroxychloroquine at the dose of 200 mg, presented significantly lower expression of type 9 TLRs in the epider"]
