Search for: [Abstract = "pancreatic edema, leukocyte infiltration and vacuolization of acinar cells, and led to earlier regeneration of the pancreas. Biochemical indexes of the severity of pancreatitis, such as serum activity of lipase and amylase were significantly reduced in animals treated with obestatin. These effects were associated with an increase in pancreatic DNA synthesis and a decrease in serum level of pro\-inflammatory interleukin\-1β. Administration of obestatin has improved pancreatic blood flow in rats with acute pancreatitis.Conclusions\: \(1\) Obestatin exhibits protective and therapeutic effect in the pancreas. \(2\) Administration of obestatin before and during the induction of acute pancreatitis inhibits the development of this inflammation. \(3\) Administration of exogenous obestatin after induction of acute pancreatitis reduces severity of acute pancreatitis and accelerates pancreatic recovery in this disease. \(4\) These beneficial effects of obestatin administration are related, at least in part, to the improvement of pancreatic blood flow and pancreatic cell vitality, as well as to reduction in the release of pro\-inflammatory interleukin\-1β."]

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