Search for: [Abstract = "ounds with log P > 3 had lower stability. Compounds with log P > 4 \(4 and 5\) were characterized by the N\-dealcylation, O\-dealcylation and less frequently C\-dealcylation manner of biotransformation, while structures with lower log P \(1\(a\-c\),\-3,7,9\) preferred oxidative metabolism not associated with the degradation of the structure.The obtained results are very applicable. They allowed us to choose the most stable compounds \(6,8,10\), which contributes to the rational selection of test connections with a defined activity in the central nervous system for further testing. Moreover, predicting moieties susceptible to the biotransformation enzymes in the unstable compounds \(1\(a\-c\),4,5,7\) contribute to make structural modifications to create more stable connections."]

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