Search for: [Abstract = "or analyzes carried out at the protein level. It has been observed that gastrin and Gly\-gastrin at a specific concentration of 1o·6 and 1o·5 \[M\] have trophic effects, and have an effect on the P\-catenin protein and the activity of PP ARy receptors. The increase in P\-catenin expression may affect the PPARy nuclear receptor activity, however, this effect was only noticeable in the PANC\-1 cell line. In tum, in the OE\-33 cell line, induction of B\-catenin protein was observed to weaken PP Ary receptor activity. The obtained results confirm the thesis that in some gastrointestinal neoplasms we observe a decrease in PP ARy activity with a simultaneous increase in the activity of the WNT\-P\-catenin pathway due to the action of gastrin precursors. An increase in the activity of the WNT\-P\-catenin pathway is conducive to inhibiting the process of apoptosis by increasing the expression of P\-catenin protein in the studied tumor cell lines."]
